PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide and a non-selective agonist of the melanocortin receptors. Structurally, it is a metabolite of Melanotan II but lacks the C-terminal amide functionality, significantly reducing its affinity for the MC1 receptor (responsible for pigmentation). It is primarily utilised in research to understand the central nervous system's role in physiological arousal pathways.
PT-141 functions via the activation of central melanocortin receptors, specifically MC3R and MC4R, located in the hypothalamus. Unlike vascular-acting agents (such as PDE5 inhibitors), PT-141 modulates dopamine signalling pathways in the brain to influence downstream physiological arousal. Research focuses on its ability to trigger neural excitatory signals independent of the vascular system.
This product is sold for in-vitro laboratory research purposes only. It is not a drug, food, or cosmetic and is not intended for human or veterinary consumption. All handling should be performed by qualified professionals in a controlled laboratory setting. Forge Peptides is not liable for any misuse of this product. By purchasing, you agree that you are a qualified researcher or a scientific professional.
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