MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded within the mitochondrial DNA, not the nucleus. It is classified as a "mitochondrial-derived peptide" (MDP). Research suggests MOTS-c acts as a signalling molecule that translocates to the nucleus in response to metabolic stress, regulating gene expression related to metabolism and homeostasis.
Research focuses on MOTS-c's role as an exercise-mimetic and metabolic regulator. Mechanism studies suggest it targets the folate-methionine cycle, reducing intracellular levels of 5-methyltetrahydrofolate (5-Me-THF), which increases AICAR levels and subsequently activates AMP-activated protein kinase (AMPK). This pathway is investigated for its ability to enhance insulin sensitivity and promote fatty acid oxidation in skeletal muscle tissue.
This product is sold for in-vitro laboratory research purposes only. It is not a drug, food, or cosmetic and is not intended for human or veterinary consumption. All handling should be performed by qualified professionals in a controlled laboratory setting. Forge Peptides is not liable for any misuse of this product. By purchasing, you agree that you are a qualified researcher or a scientific professional.
